One perennial problem I've had for as long as I can remember is that any time I play a song that uses the first fret a lot (e.g. the verses for Metallica's "Jump in the Fire" come to mind) I end up hurting my wrist real bad.
12 years of playing tells me that it's not something that's simply going to go away with time. It seems the issue is mostly with having to stretch my index finger across the neck, and the pain is primarily in my wrist right at the base of the round part of the palm.
Does anyone have any advice on what I can adjust to alleviate this issue, aside from playing songs that are predominantly in F?