The system of pitches used by an instrument or in a piece of music, or the practice of adjusting the pitches that instruments or voices produce to be in accordance with the chosen system.

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Tuning instruments based on A441 instead of A440

I read that a harmonica could be tuned in A441 plus, but I don't know what that means. How is this different than A440 tuning? If you play guitar, when you tune your instrument, is it always A440? ...