You will find that a lot of guitarists actually use amp settings that are mostly clean, and get their sounds from their pedals. For instance, Matt Bellamy from Muse uses a lot of effectsa lot of effects, including the ZVex Fuzz Factory. He has at least one custom guitar with a Fuzz Factory built into the guitar (he used it for Plug-in Baby).
Here are some points to consider when working on your sound:
- Trying to replicate another artist's sound is very educational. At the same time, don't go too far trying to make a perfect recreation of any sound, since that will drive you crazy, cost you money, and you'll never quite get there anyway.
- Related to the above, a lot of an artist's sound is in their fingers and their playing style. I remember reading a column in a guitar magazine of a guitarist who was excited to play Eddie Van Halen's actual setup during a sound check for a Van Halen show. The columnist was disappointed that he still didn't sound much like Eddie Van Halen, even when using his exact rig.
- With those two items in mind, you should probably spend only half your time chasing other artist's tones, and the other half finding your sound. Find settings that make your equipment sound its best, and also find settings and effects that just make you feel good about playing. Before you know it, you'll have a sound that you like that doesn't sound quite like anyone else. Even if you're playing covers, this is the only way to sound your best - by sounding like you.
- For gain and distortion settings, always try less. Most of the thick, meaty distortion tones you hear on recordings are actually made with surprisingly low gain settings. Some artists and songs do have a lot of gain on them, but the thicker and chunkier sounds usually have less gain, while the smooth, liquid, almost "nice" sounds are more likely the high gain ones.
- You can spend a lifetime learning to dial in a tone stack (treble, mid, and bass knobs), and then have to start almost from scratch when you get a new amp. One way to get a handle on your tone controls is to turn them all the way down, then listen with them all down, each one all the way up (one at a time), and all of them all the way up. That will give you a sense of the range of each control. You may find that switching guitars, changing pedals, changing rooms, etc., all make a difference in the ideal tone control settings. Frankly, I almost always turn all the tone controls all the way up and shape my sound in other ways (different guitars, pedals, etc), because I just go insane trying to make micro adjustments to tone stacks.
- Reverb is totally situational. I tend to turn around during a gig and set my reverb differently for different songs. With enough practice, I know what reverb setting I want. For recording, I leave reverb off and do studio reverb effects and/or plugins. For playing for fun, I do it like a gig - adjust it between songs. Sometimes I like to just crank the reverb all the way up and play a sleepy blues solo that sounds really sad and far away because of the reverb.