I don't know about that, but it's worth mentioning that traditional classical guitar strings are hand-made from sheep gutsheep gut, which means that they are not perfectly geometrically uniform.
It's still possible to obtain sheepNylon guitar strings were not invented until the late 1940s; up until that time, gut strings were the only option for classical guitar. TheyNylon strings, which are a lot more durable and long-lasting, as well as louder, rapidly became very popular, and now they are the standard for classical guitar.
Sheep gut strings have remained popular to this day for the ukulele.
Sheep gut strings are also still used by musicians today who study historical performance practice in Renaissance and Baroque music, for instruments like the lute, Baroque guitar, and especially the Baroque violin, viola, cello and bass.
And some upright bass players, for instance in rockabilly music, still favor sheep gut strings.
It goes without saying that sheep gut strings sound very different than metal-core strings, but they also sound different than nylon strings.