The arrangement of strings on the guitar means that certain voicings are difficult to achieve whereas others are easier. This also leads to the fact that several voicings, or as we call them, chord shapes, are available for most chords.
As it happens, the other day I was required to play a C7b5 chord: C E Gb Bb. It was imperative to find a shape that does not have two strings with a single tone differing between them (i.e. E and Gb, aka F#, Bb and C). In the end, I found a voicing 3rd fret on the fifth string (C), 4th fret on the fourth fret (Gb), 3rd fret on the third string (Bb) and 5th fret on the second string (C). This is a completely different voicing from the chord in root position, and in fact helps by moving the E from its position where it might clash with the Gb, to the top.
Not connected: this is an interesting chord in that it is made up of two tritones.