This question is related to this question. Seeing as Jimi often played his strat upside down. What effect would that have on his bridge pickup and his sound in general?
The normal bridge pickup angle captures more higher harmonics from the higher strings than from the lower ones, and also gets more of the fundamental from the lower strings. In Jimi's case, the angle, and therefore the effects, are reversed. It should make his higher strings sound more mellow compared to a non-modified Strat, and his bass strings brighter, but possibly a little lacking in low-end.
I doubt the effect is dramatic, but I'm sure experienced guitarists could hear and/or feel the difference.
See also: Dick Dale