No, for a small studio, other than the cost difference, you can use TRS in the place of TS cables.
When you start looking at cable runs over around six meters (20 feet) you can start seeing some issues with resistance, depending on what you are using the wire for. The dual wire TRS cable will sometimes have a smaller gauge wire than the coaxial cable that is often used for TS.
Usually there is no significant difference though.
EDIT: thinking about it, there may be some slight durability difference in the two types of cables as well, if you are using the TRS cables in applications where they get flexed often, such as for a guitar cable. The tensile strength of the single wire is likely higher, resulting in a longer life before breakage in high flex use.