While Tim and Todd's answers are correct about other types of guitar music more generally, this arrangement in particular is acoustic fingerstyle, which has other considerations for notation - this is not strictly a palm or fretting hand mute.
A distinctive element of this style of playing is the use of a range of percussive techniques to add texture to the arrangement, and these are usually marked with cross-head notes like this. Since this is a fairly niche notational requirement, there is little consensus on the best way to do this, and it is often not sensible to be consistent from piece to piece. Because of this, some transcribers will explicitly detail and comment the desired percussive action(s) - I have a Jon Gomm transcription somewhere that came with about 3 additional pages of performer's notes! However, others (as here) will leave it to the player to determine the most appropriate way to achieve the marked sound, especially in simpler pieces.
In this instance, as Bradd notes in his comment, the intention is that the player should (fairly gently) slap the marked string with the thumb to produce a percussive snare-like backbeat. Fortunately, the arranger has posted their performance on youtube where you can see this in action, particularly at 0:43.