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Fixed grammar in the title.
Todd Wilcox
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How does the choice of strings impact sound and playability?

I recently bought a classic series '50s Fender Telecaster. Beautiful guitar with 2 peculiar vintage-style pickups and vintage-style machine heads. It's best when I play classic rock songs, with clean channel tube amp.

I'm wondering if the choice of the strings on this guitar could have a very significant impact on its sound and playability. Which factors have to be considered in the choice of the strings?