A good thing about Guitars is that these were not traditionally part of the Classical Music Instrument Families but rather one that came to a good from only around the late 18th Century. These have roots from different Instruments especially the Lute just to mention.
Since Guitars weren't a part of Traditional Instrument Families, You have the freedom to choose the way you play it (Unlike Piano or Violin). Playing the Piano like a Keys player will only get people to look at you like you are a noob but thats not the case with guitars.
Getting some riffs fuzzy here and there might be a small compromise, More like playing music written for say a Violin in a Piano (I'm talking of how the Fretboard of Violin and Octaves of Piano are differently arranged, I'm not talking about Timbre here).
If you write Music yourself, Using an Upside-Down guitar might give you power at certain places. You djent with Ease in low registers for instance. But there's one con for this inverted Stringing which if you are just a Jamming/Songwriting person doesn't matter but If you are serious about music and later might even be writing for extended Music groups, Your sense of Locating Notes will be incoherent with how other instruments work. Adapting to a new instrument will be hard. It will take you longer to understand how a Violinist plays and how to write for him/her.
I guess that's all. Just one last thing. It how expressive you music is and how resilient your playing is that decides everything. Just make sure you get the point straight that you are different, not a noob.
